What are the 3 cell cycle “checkpoints?”

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G1 checkpoint
G2 checkpoint
Spindle checkpoint

G1 check point

is the main check point that controls if cell continue to divide or stop dividing this depends on many factors :
1. type of cell eg neuron will stop dividing and enter G0 while skin cell will continue to divide
2.if cell have enough nutrients , Growth factors , appropriate size , free from DNA defects

G2 check point

occurs between G2 and : it makes sure that replication of DNA occurred completely and there are no , if there are mutations they must corrected first before going into mitosis , if they cannot be corrected the cell must die to prevent future cells from carrying this defect

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Spindle check point

occur between metaphase and anaphase to make sure chromosomes are attached to the spindles.


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